Faculty

Steven Freedman
Collaborating Investigator

Dr. Freedman received his Ph.D. from Yale University School of Medicine in 1981 followed by the M.D. degree at the University of Connecticut in 1986. He completed his residency and fellowship in Gastroenterology at Beth Israel Hospital and has remained on faculty since 1991. Dr. Freedman’s expertise is in exocrine pancreatic disease with a particular focus on pancreatitis and cystic fibrosis in both adults and children. He is an internationally recognized leader in these areas with an extensive research program that encompasses both basic science as well as clinical trials of new therapies for pancreatitis and cystic fibrosis. Dr. Freedman’s group is currently testing a new noninvasive therapy for the treatment of pain due to chronic pancreatitis in a study funded by the National Institutes of Health. In addition, his group has identified an association between cystic fibrosis gene mutations and the development of chronic pancreatitis and Primary Sclerosing Cholangitis. As a result, his group is currently testing new therapies for both of these diseases.

Dr. Freedman is on the editorial board of Pancreatology and is a major reviewer for multiple journals. He is a member of the American Gastroenterological Association, American Pancreatic Association, and Cystic Fibrosis Foundation (both and ).  He has spoken nationally and internationally on chronic pancreatitis and cystic fibrosis. He is on the board of directors for the National Pancreas Foundation and is the chairman of their Grant Review Council.

Relevant Publications

1. Freedman SD, Katz MH, Parker EM, Laposata M, Urman MY, and Alvarez JG.  A membrane

      lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr^-/- mice.

      Proc. Natl. Acad. Sci. 1999, 96:13995-14000.

2. Freedman SD, Kern H and Scheele GA. Pancreatic acinar cell dysfunction in cftr (-/-)

      mice is associated with altered luminal pH and endocytosis at the apical plasma membrane.

      Gastroenterology 2001; 121:950-957.

3. Freedman SD, Weinstein D, Blanco PG, Martinez-Clark P, Urman S, Zaman M, Morrow

      JD, and Alvarez JG. Characterization of LPS-induced lung inflammation in cftr^-/- mice and

      the effect of docosahexaenoic acid.  J. Applied Physiology, 2002, 92: 2169-2176.

4. Sheth S, Shea J, Bishop MD, Chopra S,  Regan MM, Malmberg E, Walker C, Ricci R, Tsui L-C, Durie PR, Zielenski Z, and Freedman SD.  Association of Primary Sclerosing Cholangitis with Mutations of the Cystic Fibrosis Gene. Human Genetics 2003, 113:286-292.

5. Ollero M, Junaidi,O, Zaman M, Tzameli I, Ferrando A; Andersson C Blanco P, Bialecki E and Freedman SD. Decreased Expression of Peroxisome Proliferator Activated Receptor g in CFTR ^-/- Mice. J. Cell. Physiol. 2004; 200:235-244.

6. Freedman SD, Blanco PG, Zaman MM, Shea J, Ollero M, Hopper IK, Weed DA, Gelrud A, Regan MM, Laposata M, Alvarez JG, and O’Sullivan BP. Association of Cystic Fibrosis With Abnormalities In Fatty Acid Metabolism. New Engl. J. Med, 2004; 350:560-569.

 

7. Blanco, PG, Zaman MM, Junaidi O, Sheth S, Yantiss R, Nasser I, and Freedman SD. Induction of colitis in cftr^-/- mice results in bile duct injury. Am. J. Physiol. Gastrointest Liver Physiol, 2004, 287: G491-496.

8. Bishop MD, Freedman SD, Zielenski J, Ahmed N, Dupuis A, Sheelagh M, Ellis L, Shea J, Hopper I, Corey M, Kortan P, Haber G, Ross C, Tzountzouris J, Ray PN, Tsui L-C, and Durie PR. The Cystic Fibrosis Transmembrane Conductance Regulator Gene and Ion Channel Function in Patients with Idiopathic Pancreatitis. Human Genetics; 2005, in press.

 

9. Fregni F, Monte-Silva K, Oliveira M, Freedman SD, Pascual-Leone A, Guedes RC. Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading depression: relevance for clinical applications of brain stimulation. Eur J Neurosci 2005 Apr;21(8):2278-84.

10. Fregni F, DaSilva D, Potvin K, Ramos-Estebanez C, Cohen D, Pascual-Leone A, and Freedman SD. Treatment of chronic visceral pain with brain stimulation. Ann. Neurol. 2005; in press.

11. Fregni F, Boggio PS, Mansur CG, Wagner T, Ferreira MJ, Lima MC, Rigonatti SP, Marcolin MA, Freedman SD, Nitsche MA, Pascual-Leone A. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport. 2005;16:1551-1555.

12. Pall H, Zaman MM, Andersson C, and Freedman SD. Decreased Peroxisome Proliferator Activated Receptor a is Associated with Bile Duct Injury in CFTR^-/- Mice. J. Pediatric Gastroenterology Nutrition, 2006, in press.