Matthew Burke, MD

Matthew Burke, MD
Sidney R. Baer, Jr. Foundational Fellow in the Clinical Neurosciences

Education History:
M.D, University of Toronto
B.Sc. (Honors), Life Sciences, Queen's University

Clinical Training:
Neurology Residency, University of Toronto, Canada

Research Interests:
Ever since my undergraduate studies, I have had strong interests in neurology, psychiatry and the expanding interface in between. This has led to a variety of research projects in fields of headache, concussion, neuropsychiatry, stroke, addiction and memory. In the latter half of my neurology residency, I became very interested in neuroplasticity and non-invasive brain stimulation. I initiated projects investigating neurostimulation strategies for the treatment of functional neurological disorders and rTMS for migraine prevention.

With regards to future research, I am interested in continuing to explore neurostimulation-based applications towards the previously mentioned fields but also towards areas such as concussion, stroke rehabilitation and cognitive impairment. I believe there is great potential not only for treatment but also for utilizing neurophysiology to further understand the pathogenesis of these conditions.

Clinical Interests:
My clinical interests include concussion/traumatic brain injury, cognition/memory, headache/pain, neuropsychiatry and neurorehabilitation.

Personal Interests/Hobbies:
I enjoy playing sports (such as tennis and soccer), all things food, live music and design/architecture.

Personal Goals:
During my fellowship, I hope to become a technical expert in the use of non-invasive brain stimulation devices. This includes acquiring both essential design and analysis skills but also novel approaches such as pairing brain stimulation concurrently with other interventions and using real-time/closed-loop EEG and/or fMRI guided stimulation. In parallel, I hope to apply this skill-set across a variety of clinical research areas at the neurology/psychiatry interface. I believe that these technologies will be a “game-changer” for the clinical neurosciences and I am eager to be a part of the innovation and advancement of this field.

Selected Research Publications:

  1. Burke MJ, Lamb MJ, Hohol M, Lay C. Unique CT perfusion imaging in a case of HaNDL: new insight into HaNDL pathophysiology and vasomotor principles of cortical spreading depression. Headache. 2017;57(1):129-134.
  2. Burke MJ, Fralick M, Nejatbakhsh N, Tartaglia MC, Tator CH. In search of evidence-based treatment for concussion: characteristics of current clinical trials. Brain Inj. 2015;29(3):300–305.
  3. Burke MJ, Ghaffar O, Staines WR, Downar J, Feinstein A. Functional neuroimaging of conversion disorder: The role of ancillary activation. NeuroImage: Clin. 2014;6:333-339.
  4. Burke MJ, Chundamala J, Tator CH. Deficiencies in concussion education in Canadian medical schools. Can J Neurol Sci. 2012;39(6):763-766.
  5. Burke MJ, Vergouwen MD, Fang J, Swartz RH, Kapral MK, Silver FL, Casaubon LK. Short-term outcomes after symptomatic internal carotid artery occlusion. Stroke. 2011;42:2419-2424.

Selected Abstract/Conference Presentations:

  1. Gros P, Chen R, Feinstein A, Lang AE,Burke MJ. Neurostimulation for the treatment of functional neurological disorders: novel therapeutic strategy or placebo effect? 2nd International Brain Stimulation Conference, Barcelona, Spain March 2017.
  2. Burke MJ, Beyaert M, Blichowski, Lay C, Blumberger DM, Lena S. rTMS for migraine prevention: evaluating rationale for location and frequency of stimulation. 1st International Brain Stimulation Conference, Singapore, March 2015.