Mouhsin Shafi, MD, PhD

Mouhsin Shafi, MD, PhD
Associate Professor of Neurology, Harvard Medical School
Director, Berenson-Allen Center for Noninvaisve Brain Stimulation

Education History:
MD, PhD, Medicine and Neuroscience, UCLA School of Medicine

Mo obtained his MD/PhD in Medicine and Neuroscience at the University of California, Los Angeles School of Medicine. He then completed his Neurology residency at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital in 2010, followed by a 2-year Clinical and Research Fellowship in Epilepsy and Clinical Neurophysiology at MGH. He is now an Assistant Professor in Neurology at Harvard Medical School and Director of the Berenson-Allen Center for Noninvasive Brain stimulation.

Research Interests:

The principal focus of Mo's research involves using EEG in combination with noninvasive brain stimulation techniques such as Transcranial Magnetic Stimulation (TMS) to investigate and modify human brain function and connectivity. As an example, in one recent study TMS, EEG and resting-state functional-connectivity MRI were utilized to identify cortical hyperexcitability in regions with abnormal connectivity in patients with epilepsy due to periventricular nodular heterotopia, a disorder of neuronal migration. The methods and results of this study have been published in Journal of Visualized Experiments and in Annals of Neurology, respectively. Another study investigating the effects of repetitive TMS on EEG connectivity was published in Brain Topography.

His research is also directed towards the clinical application of these tools in patients. He directed one of the first successful applications of repetitive TMS to treat a patient with medication-refractory nonconvulsive status epilepticus, published in Clinical Neurophysiology.

A second line of his work is focused on better utilizing EEG in the care of patients with seizures. In a series of investigations, has shown that interictal epileptiform discharges can predict seizures in hospitalized patients undergoing continuous EEG monitoring, and that quantitative EEG analysis techniques can be used to rapidly screen continuous EEG studies to identify seizures. These studies have led to publications in Neurology, Neurocritical Care, and Clinical Neurophysiology.

Complete List of Published Work in MyBibliography