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Peter J. Fried, PhD

Peter J. Fried, PhD
Instructor in Neurology, Harvard Medical School
Co-Director, Core for Noninvasive Brain Stimulation

Education History:
Ph.D., Anatomy and Neurobiology, Boston University School of Medicine

In 2013, Dr. Fried obtained his Ph.D. in Anatomy and Neurobiology from Boston University School of Medicine. His dissertation combined functional magnetic resonance imaging (fMRI) and repetitive transcranial magnetic stimulation (TMS) to investigate the functional organization of the dorsolateral prefrontal cortex and other brain regions responsible for working memory in humans.

From 2013-2015, Dr. Fried completed a post-doctoral fellowship at the BA-CNBS under Dr. Alvaro Pascual-Leone. This work focused on evaluating alterations in the mechanisms of cortical plasticity in older adults with type-2 diabetes mellitus, which is a major risk factor for Alzheimer’s disease.

In 2015, Dr. Fried was appointed to Instructor of Neurology and became Co-Director of the Core for Noninvasive Brain Stimulation. He also oversees the training program in TMS and the fundamentals of neurophysiology for new fellows and research assistants at the BA-CNBS.

Research Interests:
Dr. Fried’s interests are focused on using TMS in conjunction with electromyography (EMG) and electroencephalography (EEG) This knowledge has the potential to improve public health by characterizing reliable and potentially modifiable markers of cerebral function that could be translated into novel therapeutic targets for interventions to improve cognition and reduce the risk of developing dementia.

Dr. Fried has a second line of applied research to evaluate the reliability and optimize the efficacy of noninvasive brain stimulation techniques such as TMS and transcranial electric stimulation as assessments of neurophysiology and the mechanisms of brain plasticity in humans.

Featured Published Work:

  • Fried PJ, Schilberg L, Brem A-K, Saxena S, Wong B, Cypess AM, Horton ES, Pascual-Leone A. Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits. J Alzheimers Dis. 2017;55(1):89–100. https://doi.org/10.3233/JAD-160505.
  • Fried PJ, Jannati A, Davila-Pérez P, Pascual-Leone A. Reproducibility of Single-Pulse, Paired-Pulse, and Intermittent Theta-Burst TMS Measures in Healthy Aging, Type-2 Diabetes, and Alzheimer’s Disease. Front Aging Neurosci. 2017;9:263. https://doi.org/10.3389/fnagi.2017.00263.
  • Buss SS, Padmanabhan J, Saxena S, Pascual-Leone A, Fried PJ. Atrophy in Distributed Networks Predicts Cognition in Alzheimer's Disease and Type 2 Diabetes. J Alzheimers Dis. 2018;65(4):1301-1312. https://doi.org/10.3233/JAD-180570.
  • Menardi A, Pascual-Leone A, Fried PJ*, Santarnecchi E*. The Role of Cognitive Reserve in Alzheimer's Disease and Aging: A Multi-Modal Imaging Review. J Alzheimers Dis. 2018;66(4):1341-1362.https://doi.org/10.3233/JAD-180549.
  • Buss SS*, Fried PJ*, Pascual-Leone A. Therapeutic noninvasive brain stimulation in Alzheimer's disease and related dementias. Curr Opin Neurol. 2019 Apr;32(2):292-304. https://doi.org/10.1097/WCO.0000000000000669.
  • Fried PJ, Pascual-Leone A, Bolo NR. Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex. Clin Neurophysiol. 2019;130(9):1502–1510. https://doi.org/10.1016/j.clinph.2019.04.721.
  • Benwell CSY*, Davila-Pérez P*, Fried PJ*, Jones RN, Travison TG, Santarnecchi E, Pascual-Leone A, Shafi MM. EEG spectral power abnormalities and their relationship with cognitive dysfunction in patients with Alzheimer’s disease and type 2 diabetes. Neurobiol Aging. 2020;85:83–95. https://doi.org/10.1016/j.neurobiolaging.2019.10.004.
  • Buss SS, Press DZ, McDonald K, Kitchener E, O’Connor M, Donohoe K, Shafi MM, Pascual-Leone A*, Fried PJ*. LTP-like plasticity is impaired in amyloid-positive amnestic MCI but independent of PET-amyloid burden. Neurobiol. Aging. 2020. In Press. https://doi.org/10.1016/j.neurobiolaging.2020.08.021.

Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1lKG2ZKzXLJAH/bibliography/public/.