Shahid Bashir

Shahid Bashir, Ph.D
Visiting Faculty

My main research focus is in establishing cortical plasticity biomarkers using noninvasive transcranial magnetic stimulation (TMS) in combination with electroencephalography (EEG) and electromyography (EMG). Currently my research revolves around enhancing the concepts of synaptic plasticity in normal individuals either with or without pharmacological interventions with the aim of establishing robust biomarkers that can potentially measure disease phenomenon along the causal pathway and predict disease trajectory. The use of such biomarkers holds special promise for better understanding the pathophysiology behind diseases like Traumatic Brain Injury and Ageing, to name a few. I am also interested in combining navigated TMS with brain imaging to explore cross-modal plasticity following brain lesions. I graduated from the University of Punjab with a degree in Biology in 2000, from the University of Fribourg with a PhD. I am working with Alvaro Pascual-Leone at Harvard Medical School from 2008.

Selected Publications

  1. Zaheer A, Akhtar T and Bashir S (1999): Echinoucus granulosus , histopathology of naturally infected sheep liver. Punjab univ.j.zool. Vol. No. 14. 105-111. Record number: PK2001001205
  2. Diserens K , Herrmann F , Perret N , Chatelain S , Filipovic N , Bashir S , Ruegg D , Vuadens, P , Bogousslavsky J , Vingerhoets F (2007): The effect of repetitive arm cycling on post stroke spasticity and motor control. J Neurol Sci. 15; 253(1-2):18-24. PMID: 17241642 http://www.ncbi.nlm.nih.gov/pubmed/17241642
  3. Stamoulis C, Praeg E, Bashir S, Chang BS, Pascual-Leone A (2009): Estimation of Brain State Changes Associated with Behavior, Stimulation and Epilepsy. Conf Proc IEEE Eng Med Biol Soc. 4719-22. PMID: 19964837 http://www.ncbi.nlm.nih.gov/pubmed/19964837
  4. Kaeser M, Wyss A, Bashir S, Hamadjida A, Liu Y, Bloch J, Brunet JF, Saif AB and Rouiller EM (2010): Long-Term effects of Unilateral Lesion of the Primary Motor Cortex (M1) on Ipsilesional Hand Dexterity in Adult Macaque Monkeys: relationship with functional recovery of the contralesional hand. J Neurophysiol. 103(3):1630-45. PMID: 20071636 http://www.ncbi.nlm.nih.gov/pubmed/21597965
  5. Bashir S, Edwards D, and Pascual-Leone A (2010): Neuro-navigation increases the effectiveness of low-frequency rTMS on primary motor cortex in healthy subjects. Brain Topogr. (ahead of press on-line publication Nov 13). PMID: 21076861http://www.ncbi.nlm.nih.gov/pubmed/21076861
  6. Oberman L, Ifert-Miller F, Najib U, Bashir S, Woollacott I, Gonzalez-Heydrich J, Picker J, Rotenberg A and Pascual-Leone A (2010): Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile X syndrome and autism spectrum disorder. Front. Syn. Neurosci. 2:26. (ahead of press on-line publication Nov 13) doi:10.3389/fnsyn.2010.00026 http://www.ncbi.nlm.nih.gov/pubmed/21423512
  7. Stamoulis S, Oberman L, Praeg E, Bashir S, Pascual-Leone A (2011): Single Pulse TMS-Induced Modulations of Resting Brain Neurodynamics Encoded in EEG Phase. Brain Topogr. PMID: 21203817 http://www.ncbi.nlm.nih.gov/pubmed/21203817
  8. Bashir S, Kaeser M, Wyss A, Hamadjida A, Liu Y, Bloch J, Brunet JF, Belhaj-Saif A, Rouiller EM. Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys. Brain Struct Funct. 2011 May 20. PMID: 21597965 http://www.ncbi.nlm.nih.gov/pubmed/21597965
  9. Freitas C, Perez J, Knobel M, Tormos JM, Oberman L, Eldaief M, Bashir S, Vernet M, Peña-Gómez C, Pascual-Leone A. Changes in cortical plasticity across the lifespan. Front Aging Neurosci. 2011; 3:5. PMID: 21519394 http://www.ncbi.nlm.nih.gov/pubmed/21842407
  10. Bashir S, Mizrahi I , Weaver K , Fregni F, Pascual-Leone A (2010): Assessment and modulation of neuroplasticity in rehabilitation with transcranial magnetic stimulation. Physical Medicine and Rehabilitation. 2 (12) Supplement: S253-S268. DOI: 10.1016/j.pmrj.2010.10.015)http://www.ncbi.nlm.nih.gov/pubmed/21172687
  11. Naeser MA, Martin PI, Treglia E, Ho M, Kaplan E, Bashir S, Hamilton R, Coslett HB, Pascual-Leone A (2010): Research with rTMS in the treatment of aphasia. Restor Neurol Neurosci. 28 (4):511-29. PMID: 20714075 http://www.ncbi.nlm.nih.gov/pubmed/20714075
  12. Najib U, Bashir S, Edwards D, Rotenberg A, Pascual-Leone A (2011): Transcranial Brain Stimulation: Clinical Applications and Future Directions. Neurosurgery Clinics of North Americahttp://www.ncbi.nlm.nih.gov/pubmed/21435574
  13. Naeser MA, Martin P , Ho M, Treglia E, Kaplan E, Bashir S, Pascual-Leone A (2011): Transcranial Magnetic Stimulation and Aphasia Rehabilitation. Article for Summer Supplement, on Language-based Disorders in Rehabilitation For Archives of Physical Medicine and Rehabilitation http://www.ncbi.nlm.nih.gov/pubmed/22202188
  14. Pascual-Leone A, Freitas C, Oberman L, Horvath JC, Halko M, Eldaief M, Bashir S, Vernet M, Shafi M, Westover B, Vahabzadeh-Hagh AM, Rotenberg A. Characterizing Brain Cortical Plasticity and Network Dynamics Across the Age-Span in Health and Disease with TMS-EEG and TMS-fMRI. Brain Topogr. 2011 Aug 14. http://www.ncbi.nlm.nih.gov/21842407